The dominant approach to decision-making in public health policy for infectious diseases relies heavily on expert opinion, which often applies empirical evidence to policy questions in a manner that is neither systematic nor transparent.Although systematic reviews are frequently commissioned to inform specific components of policy (such as efficacy
Common genetic variants in the repressive GATA-family transcription factor (TF) TRPS1 locus are associated with breast cancer risk, and luminal breast cancer cell lines are particularly sensitive to TRPS1 knockout.We introduced an inducible degron tag into the native TRPS1 locus within a luminal breast cancer cell line to identify the direct target
Abstract This study investigates the impact of bee pollen nutrition on the royal jelly production of honey bees (Apis mellifera).Results demonstrate that pollen diet significantly impacts hypopharyngeal gland (HPG) development and the expression of genes associated with royal jelly biosynthesis.Bees fed Brassica napus American Cookies and Cakes pol
Synaptotagmin-1 (Syt1) acts as a Ca2+ sensor for neurotransmitter release through its C2 domains.It has been proposed that Syt1 promotes SNARE-dependent fusion mainly through its C2B domain, but the underlying mechanism is poorly understood.In this study, we show that the C2B domain interacts simultaneously with acidic membranes and SNARE complexes